Paper summary: Why is it so difficult to predict the changes in stability that result when a protein is mutated? Our new review explains it.

Louis and Abriata. Molecular Biotechnology 2021 [open access here]

In new work just out in Molecular Biotechnology we reviewed a detailed dataset of protein stability changes upon mutations for proteins that have high-resolution structures in the PDB. It turns out that in many, many cases, there are structural subtleties that override any global effects that human experts or computer programs…